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KMID : 0903519970400050447
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Journal of the Korean Society of Agricultural Chemistry and Biotechnology
1997 Volume.40 No. 5 p.447 ~ p.450
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Structure-Activity Relationships of Fungicidal N-Substituted Phenyl 1 , 3 , 5-Trimethylpyrazole-4-carboxamides in the Inhibition of Succinate Dehydrogenase(SDH) Isolated from Rhizoctonia solni Kuhn
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Abstract
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Eighteen N-substituted phenyl 1, 3, 5-trimethylpyrazole-4-carboxamides were synthesized to screen for their mycelial growth inhibition activity against Rhizoctonia solani Ku¨hn (pEC_(50)) and to measure enzymatic inhibition activity of these compounds (pI_(50)) against succinate dehydrogenase (SDH) isolated from R. solani Ku¨hn. A structure-activity relationship formulated by regression analysis showed that 79% of the variance in mycelial growth inhibition activity can be explained with SDH inhibition activity and chromatographic capacity factor (k´) as a hydrophobic parameter related to the penetration and transport processes in the biological system.
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